Definition
- Hemolytic-uremic syndrome (HUS) is a systemic thrombotic microangiopathy with multiple causes.
- It is characterized by the classic triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney failure.
- The end result is endothelial lesions leading to thrombosis of the microcirculation in many organ systems (Table 269-1).
- HUS is divided into 2 types, depending on whether the patient has had diarrhea.
- Presence of diarrhea is designated D+ HUS.
- Most common type
- Caused by toxins from a group of Enterobacteriae, enterohemorrhagic Escherichia coli (EHEC)
- Absence of diarrhea is designated D– HUS.
- Only 10% of cases are classified as D– HUS.
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