Amphotericin B deoxycholate

Intravenous

• 0.25–0.5 mg/kg/day initially; increase as tolerated to 0.5–1.5 mg/kg daily
• Infuse as a single dose over 2 hr
• 0.5–1.0 mg/kg weekly for suppressive therapy

Intrathoracic

• 0.025 mg; increase to 0.5 mg, twice a week

Amphotericin B lipid complex (Abelcet)

• 5 mg/kg daily IV, infused over 2 hr
• Experience with drug in children is limited.
• Limited or no information about use in newborn infants is available.

Amphotericin B cholesteryl sulfate complex (Amphotec)

• 3–6 mg/kg daily IV, infused at a rate of 1 mg/kg/hr
• Experience with drug in children is limited.
• Limited or no information about use in newborn infants is available.

Liposomal amphotericin B (AmBisome)

• 3–5 mg/kg/day IV, infused over 1–2 hr
• Experience with drug in children is limited.
• Limited or no information about use in newborn infants is available.