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AAP Textbook of Pediatric Care

Chapter 62: Preoperative Assessment

Aaron L. Zuckerberg, MD; Lynne G. Maxwell, MD
Table 62-4: Drugs That Prolong the QT Interval or Induce Torsades de Pointes

Generic Name Brand Name Category*
Albuterol Ventolin, Proventil 3
Amantadine Symmetrel 2
Amiodarone Pacerone, Cordarone 1
Amphetamine/dextroamphetamine Adderall 3
Atomoxetine Strattera 3
Azithromycin Zithromax 2
Chloral hydrate Noctec 2
Chloroquine Arelan 1
Chlorpromazine Thorazine 1
Clarithromycin Biaxin 1
Clozapine Clozaril 2
Dextroamphetamine Dexadrine 3
Disopyramide Norpace 1
Dobutamine Dobutrex 3
Dolasetron Anzemet 2
Dopamine Intropin 3
Droperidol Inapsine 1
Ephedrine Rumatuss 3
Epinephrine Primatene, Bronkaid 3
Erythromycin Erythrocin , EES 1
Felbamate Felbatrol 2
Flecainide Tambocor 2
Foscarnet Foscavir 2
Fosphenytoin Cerebyx 2
Gemifloxacin Factive 2
Granisetron Kytril 2
Halofantrine Halfan 1
Haloperidol Haldol 1
Isoproterenol Isupres, Medihaler-Iso 3
Isradipine Dynacirc 2
Levalbuterol Xopenex 3
Levofloxacin Levaquin 2
Lithium Lithobid, Eskalith 2
Metaproterenol Alupent, Metaprel 3
Methadone Dolophine, Methadose 1
Methylphenidate Ritalin , Concerta 3
Milodrine ProAmantine 3
Moxifloxacin Avelox 2
Nicardipine Cardene 2
Norepinephrine Levophed 3
Octreotide Sandostatin 2
Ofloxacin Floxin 2
Ondansetron Zofran 2
Pentamidine Pentam, NebuPent 1
Phenylephrine Neosynephrine 3
Pimozide Orap 1
Procainamide Pronestyl 1
Pseudoephedrine PediaCare, Sudafed 3
Quetiapine Seroquel 2
Quinidine Quinaglute, Cardioquin 1
Risperidone Risperdal 2
Salmeterol Serevent 3
Sotalol Betapace 1
Tacrolimus Prograf 2
Telithromycin Ketek 2
Terbutaline Brethine 3
Thioridazine Mellaril 1
Tizanidine Zanaflex 2
Venlafaxine Effexor 2
Ziprasidone Geodon 2
Drugs in bold type are commonly used in perioperative period.
Drugs in italics type are commonly used in children.
*Category 1: Drugs that are generally accepted by authorities to have a risk of prolonging the QT interval and causing Torsades de pointes.
Category 2: Drugs that may prolong the QT interval but at this time lack substantial evidence for causing Torsades de pointes.
Category 3: Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome (in addition to drugs in categories 1 and 2).
A continuously updated and complete list of drugs that prolong QT, as well a list of drugs which do not prolong QT and are therefore safe in patients with long QT, may be found at www.torsades.org/medical-pros/drug-lists/drug-lists.htm#. (Accessed July 21, 2006.)

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Amantadine
Amantadine
Amiodarone
Atomoxetine
Bleomycin
Bupivacaine
Cefazolin
CeFAZolin
Chloral Hydrate
Chloroquine
Chorionic Gonadotropin
Clozapine
Common Causes of Postoperative Fever
Common Innocent Murmurs
Cosyntropin
Dantrolene
Dextroamphetamine
Dextroamphetamine and Amphetamine
Digoxin
Disopyramide
Dolasetron
DOXOrubicin
Droperidol
Drugs That Prolong the QT Interval or Induce Torsades de Pointes
Endocarditis Prophylaxis
EPHEDrine
Felbamate
Fever Due to Drugs
Flecainide
Fludrocortisone
Fluticasone
Foscarnet
Foscarnet
Fosphenytoin
Furosemide
Granisetron
Hydrocortisone
Infective endocarditis
Insulin Glargine
Insulin Regular
Isoproterenol
Isradipine
Levalbuterol
Levofloxacin
Levothyroxine
Mannitol
Metaproterenol
MethylPREDNISolone
Midazolam
NiCARdipine
Ofloxacin
Pancuronium
Pentamidine
Phenylephrine
Pimozide
Postoperative Wound Infections
Potassium Iodide
Preoperative Assessment
Procainamide
Propofol
Pseudoephedrine
QuiNIDine
Risperidone
Salmeterol
Sotalol
Succinylcholine
Tacrolimus
Terbutaline
Thioridazine
Venlafaxine
Warfarin